Mundipharma Laboratories GmbH and its independent associated company, Purdue Pharmaceuticals LP, today announced that they have entered into a global multi programme discovery and development collaboration with Laboratorios Esteve, S.A. to bring to market important next generation products for the management of pain. Under the agreements Mundipharma and Purdue could potentially make payments to Esteve exceeding US$ 1 bn if all development, regulatory and sales milestones are met across the different programmes.
The agreements bring together mid‐sized, privately owned companies in a strategic collaboration that leverages their individual strengths, combining Mundipharma’s and Purdue’s commitment to the development and commercialisation of novel pain treatments together with Esteve’s extensive pain focused research and development expertise, particularly in the field of sigma‐1 receptor biology, where they have been R&D leaders for over 10 years.
One of the assets covered by the collaboration is E‐52862, a first‐in‐class new chemical entity targeting the sigma‐1 receptor pathway, which is currently in Phase 2 trials covering multiple neuropathic pain indications.
The collaboration also includes access to MuMo‐1, the lead asset of Esteve´s Multi‐Modal (MuMo) technology platform which is currently in preclinical development with the potential to enhance sigma‐1 asset properties through the introduction of additional characteristics that are tailored for specific disease states. Mundipharma and Purdue will have primary commercial rights for this asset and Esteve retains rights in certain territories.
Also included in the agreement is E‐58425, a novel first‐in‐class patented API:API co‐crystal of tramadol and celecoxib which has been studied in acute postoperative pain. The collaboration envisages Esteve commercialising E‐58425 in the USA and Mundipharma in the rest of the world.
For Mundipharma and Purdue, the partnership will see the companies expand their pain franchise into neuropathic, acute and moderate pain in addition to existing expertise in opioids and severe pain. For Esteve, the agreements validate its consistent investment into innovative R&D as well as its continued emphasis on identifying novel approaches to treat the significant unmet medical needs of people living with pain.
Commenting on the partnership, Antony Mattessich, Managing Director, Mundipharma International, said: “We are very excited about the opportunity to work with Esteve and the prospects for growth the partnership will bring. This strategic collaboration leverages the companies’ individual strengths, with our ability to bring products from the clinical process through to successful commercialisation complementing Esteve’s focus on discovering new molecules and approaches to the treatment of pain in the laboratory. Mundipharma, Purdue and Esteve are committed to driving innovation in the pain management space, so the collaboration is a natural fit.”
Albert Esteve, Chief Executive Officer (CEO) of Esteve, said: “By combining Esteve’s, Mundipharma’s and Purdue’s complementary strengths and capabilities, we are creating opportunities to improve pain treatment options for patients and reaffirming our ongoing commitment to pain management. With our pain pipeline and Mundipharma’s and Purdue’s development, market access and commercialisation strengths, we are well‐placed to work together to bring innovative new treatments to patients suffering from pain.”
The global pain market is valued at $37 bn. The neuropathic pain market is valued at $5.3 bn across US and EU5 with a Compound Annual Growth Rate (CAGR) of 8% over the past five years.

Source: From press release published on